杨明英

1993年9月--1998年7月:浙江农业大学蚕学系   农学学士

1998年9月--2001年7月:浙江大学动物科学院   农学硕士

2001年10月--2002年3月:东京农工大学工学部生命工学科   进修生

2002年4月--2005年3月:东京农工大学工学部生命工学科   工学博士

2005年4月--2007年8月:东京农工大学工学部生命工学科   博士后研究员

2007年9月--2014年12月: 浙江大学动物科学院生物资源应用研究所   副研究员 硕士生导师

2015年1月--至今: 浙江大学动物科学学院生物资源应用研究所  教授 博士生导师
 

浙江省蚕桑学会副秘书长；

全国专业标准化技术委员会委员；

中国生物材料学会会员；

浙江省农作物品种桑蚕新品种审定专家组成员

浙江省151人才工程第三层次培养人员；

SCI国际期刊Microscopy Research & Technique编委与guest editor

1. 家蚕丝�野蚕丝以及蜘蛛丝蛋白的结构解析；

2. 功能重组丝蛋白的设计；

3. 丝蛋白骨组织工程支架的设计；

4. 丝蛋白对纳米无机材料自组装的调控。
 

1、863计划子课题，2013AA102507-1、家蚕驯化性状的功能基因组研究：茧丝性状功能基因、2013/01-2017/12、主持；

2、国家自然科学基金面上项目，21172194、重组蜘蛛丝蛋白的设计及其分子自组装对生物矿化功能调控的研究、2012/01-2015/12、主持；

3、浙江省自然基金重点项目，LZ12C17001、重组蜘蛛丝蛋白纳米支架的设计及其羟基磷灰石复合体的研究、2012/01-2014/12、主持；

4、国家自然科学基金，20804037、水溶性重组丝蛋白的设计、结构特征及其对纳米纤维形成关系的研究、2009/01-2011/12、主持；

5、浙江省留学人员科技活动择优项目，J20110117、水溶性重组丝蛋白的电子纺丝、2011/01-2011/12、主持；

6、高等学校博士学科点专项科研基金项目，200803351017、水溶性重组丝蛋白的分子设计、表达及其结构特征、2009/01-2011/12、主持。

SCI论文

1.   Mingying Yang*, Guanshan Zhou, Yajun Shuai, Jie Wang, Liangjun Zhu and Chunbin Mao*.Ca²⁺-induced self-assembly of Bombyx mori silk sericin into a nanofibrous network-like protein matrix for directing controlled nucleation of hydroxylapatite nano-needles. Journal of Materials Chemistry B, 2015, 3: 2455-2462.

2.   Meng Wang*, Ming Li, Mingying Yang*, Xiaomei Zhang, Aoyang Yu, Ye Zhu, Penghe Qiu and Chunbin Mao*. NIR-induced highly sensitive detection of latent fingermarks by NaYF4:Yb,Er upconversion nanoparticles in a dry powder state. Nano Research, 2014，DOI: 10.1007/s12274-014-0686-7

3.    Mingying Yang^*, Guanshan Zhou, Harold Castano-lzquierdo, Ye Zhu and Chuanbin Mao^*, Biomineralization of natural collagenous nanofibrous membranes and their potential use in bone tissue engineering, Journal of Biomedical Nanotechnology, 2015, 11 (3): 447-456.

4.    Jianglin Wang, Lin Wang, Mingying Yang^*, Ye Zhu, Antoni Tomsia and Chuanbin Mao^*, Untangling the effects of peptide sequences and nanotopographies in a biomimetic niche for directed differentiation of iPSCs by assemblies of genetically engineered viral nanofibers, Nano Leters, 2014, 14(12): 6850-6856.

5.    Jianglin Wang, Mingying Yang^*, Ye Zhu, Lin Wang, Antoni P. Tomsia and Chuanbin Mao^*, Phage nanofibers induce vascularized osteogenesis in 3D printed bone scaffolds, Advanced Materials, 2014, 26 (29): 4961-4966.

6.    Mingying Yang^*, Yajun Shuai, Guanshan Zhou, Namita Mandal, Liangjun Zhu and Chanbin Mao^*, Tuning molecular weights of Bombyx mori (B.mori) silk sericin to modify its assembly structures and materials formation, ACS Applied Materials & Interfaces, 2014, 6 (16): 13782-13789.

7.    Binrui Cao, Mingying Yang^*, Ye Zhu, Xuewei Qu and Chuanbin Mao^*, Stem cells loaded with nanoparticles as a drug carrier for in vivo breast cancer therapy, Advanced Materials, 2014, 26 (27): 4627-4631.

8.    Mingying Yang^*, Yajun Shuai, Can Zhang, Yuyin Chen, Liangjun Zhu and Chuanbin Mao^*, and Hongwei OuYang, Biomimetic nucleation of hydroxyapatite crystals mediated by Antheraea pernyi (A. pernyi) silk sericin promotes osteogenic differentiation of human bone marrow derived mesenchymal stem cells, Biomacromolecules, 2014, 15(4):1185-1193.

9.    Mingying Yang^*, Namita Mandal, Yajun Shuai, Guanshan Zhou, Sijia Min, Liangjun Zhu, Mineralization and biocompatibility of Antheraea pernyi (A-pernyi) silk sericin film for potential bone tissue engineering. Bio-medical materials and engineering 2014, 24 (1), 815-824.

10.   Mingying Yang^*, Yajun Shuai, Guanshn Zhou, Namita Mandal and Liangjun Zhu. Nucleation of hydroxyapatite on Antheraea pernyi (A-pernyi) silk fibroin film. Bio-medical materials and engineering 2014, 24 (1), 731-740.

11.   Lianxia Deng, Haiping Zhang, Mingying Yang, Namita Mandal and Liangjun Zhu^*, Improving properties of superabsorbent composite induced by using alkaline protease hydrolyzed-sericin (Aph-sericin). Polymer composites, 2014, 35 (3): 509-515.

12.  Haiping.Zhang, Xueyun.Wang, Sijia. Min, Namita. Mandal, Mingying.Yang, L.J.Zhu^*, Hydroxyapatite/sericin composite film prepared through mineralization of flexible ethanol-treated sericin film with simulated body fluids, Ceramics International, 2014, 40 (1): 985-991.

13.  Mingying Yang^*, Wen He, Yajun Shuai, Sijia Min and Liangjun Zhu, Nucleation of hydroxyapatite crystals by self-assembled Bombyx mori silk fibroin, Journal of Polymer Science Part B-Polymer Physics, 2013, 51 (9): 742-748.

14.  Mingying Yang^*, Yajun Shuai, Wen He, Sijia Min and Liangjun Zhu, Preparation of porous scaffolds from silk fibroin extracted from the silk gland of Bombyx mori (B. mori), International Journal of Molecular Sciences, 2012, 13 (6): 7762-7765.

15.  Sijia Min^*, Xin Gao, Chunmao Han, Yuyin Chen, Mingying Yang, Liangjun Zhu, Haiping Zhang, Lin Liu, Juming Yao, Preparation of a silk fibroin spongy wound dressing and its therapeutic efficiency in skin defects, Journal of Biomaterials Science-Polymer Edition, 2012, 23 (1-4): 97-110

16.  Haiping Zhang, Lianxia Deng, Mingying Yang, Sijia Min, Lei Yang and Liangjun Zhu^*, Enhancing effect of glycerol on the tensile properties of Bombyx mori cocoon sericin films, International Journal of Molecular Sciences, 2011, 12 (5): 3170-3181.

17.  Yanhong Zhang, Yinsun Ma, Mingying Yang, Sijia Min, Juming Yao, Liangjun Zhu^*, Expression, purification, and refolding of a recombinant human bone morphogenetic protein 2 in vitro, Protein Expression and Purification, 2011, 75 (2): 155-160.

18.  Mingying Yang, Junji Kawamura, Zhenghua Zhu, Kazuo Yamauchi, Tetsuo Asakura, Development of silk-like materials based on Bombyx mori and Nephila clavipes dragline silk fibroins, Polymer, 2009, 50 (1): 117-124.

19.  Mingying Yang, Chikako Tanaka, Koji Yamauchi, Kotsuke.Ohgo, Tetsuo Asakura^* and M. Kurokawa. Silk-like materials constructed from sequences of Bombyx mori silk fibroin, fibronectin and elastin. Journal of Biomedical Materials research: Part A 2008, 84(2), 53-363.

20.  Mingying Yang, T. Muto, David Knight, A.M. Collins, Tetuso Asakura^*. Synthesis and Characterization of Silklike Materials Containing the Calcium-Binding Sequence from Calbindin D9k or the Shell Nacreous Matrix Protein MSI60. Biomacromolecules 2008，9(1), 416 – 420.

21.  Haiping Zhang, Mingying Yang, Sijia Min, Qiang Feng, Xin Gao, Liangjun Zhu, Preparation and characterization of a novel spongy hydrogel from aqueous Bombyx mori sericin, E-Polymers, 2008.

22.  Mingying Yang, Kazuo Yamauchi., M. Kurokawa, Tetuso Asakura^*.  Design of silk-like biomaterials inspired by mussel adhesive protein. Tissue Engineering 2007, 13(12), 2941-7.

23.  Tetsuo Asakura^*, Hirohiko Sato, Fumika Moro, Mingying Yang, Yasumoto Nakazawa, Andrew M. Collins, and David Knight, Solid-state NMR analysis of (GA)₃S(AG)₃D(GA)₃S(AG)₃D(GA)₃S(AG)₃, a peptide with a lamellar structure and a calcium binding site, and production of TS[(AG)₃D(GA)₃S] (16) in Escherichia coli, Macromolecules, 2007, 40 (25): 8983-8990.

24.  Tetsuo Asakura^*, Juming Yao, Mingying Yang, Zhenghua Zhu, Haruko Hirose, Structure of the spinning apparatus of a wild silkworm Samia cynthia ricini and molecular dynamics calculation on the structure change of the silk fibroin, Polymer, 2007, 48 (7): 2064-2070.

25.  Mingying Yang, Yasumoto Nakazawa, Kazuo Yamauchi, David Knight, and Tetsuo Asakura^*, Structure of model peptides based on Nephila clavipes dragline silk spidroin (MaSp1) studied by ¹³C cross polarization/magic angle spinning NMR, Biomacromolecules, 2005, 6 (6): 3220-3226.

26.  Mingying Yang, Tetsuo Asakura^*, Design, expression and solid-state NMR characterization of silk-like materials constructed from sequences of spider silk, Samia cynthia ricini and Bombyx mori silk fibroins, Journal of Biochemistry, 2005, 137 (6): 721-729.

27.  Tetsuo Asakura^*, Mingying Yang, Taiji Kawase, and Yasumoto Nakazawa, C-13 solid-state NMR study of structure heterogeneity in peptides containing both polyalanine and repeated GGA sequences as a local structure model of Nephila clavipes dragline silk (Spidroin 1), Macromolecules, 2005, 38 (8): 3356-3363.

28.  Mingying Yang, Juming Yao, Masashi Sonoyama, and Tetsuo Asakura^*, Spectroscopic characterization of heterogeneous structure of Samia cynthia ricini silk fibroin induced by stretching and molecular dynamics simulation, Macromolecules, 2004, 37 (9): 3497-3504.

29.  Tetsuo Asakura^*, Chikako Tanaka, Mingying Yang, Juming Yao, Masato Kurokawa, Production and characterization of a silk-like hybrid protein, based on the polyalanine region of Samin cynthia ricini silk fibroin and a cell adhesive region derived from fibronectin, Biomaterials, 2004, 25 (4): 617-624.

30.  Tetsuo Asakura^*, Mingying Yang, and Taji Kawase, Structure of characteristic sequences in Nephila clavipes dragline silk (MaSp 1) studied with ¹³C solid state NMR, Journal of Polymer, 2004, 36 (12): 999-1003.

31.  Tetsuo Asakura^*, Koji Nitta, Mingying Yang, Juming Yao, Yasumoto Nakazawa, and David L. Kaplan, Synthesis and characterization of chimeric silkworm silk,       Biomacromolecules, 2003, 4 (3): 815-820.