返回顶部基本信息
| 姓 名 | 张坤 |  | |
| 职 称 | 研究员 | ||
| 导师类别 | 博士生导师 | ||
| 招生方向 | 动物早期胚胎发育, 动物表观遗传学, 动物基因编辑 | ||
| 联系方法 | 电话 | 0571-88982506 | |
| Email | kzhang@zju.edu.cn | ||
返回顶部教育背景与工作简历
2015年8月-至今 研究员，浙江大学动物科学学院
2013年8月-2015年7月 助理教授，美国密歇根州立大学动物科学系
2011年7月-2013年7月 博士后，美国马萨诸塞大学兽医及动物科学系
2007年8月-2011年7月 博士，美国佛罗里达大学动物科学系
2004年9月-2007年7月 研究生，中国农业大学生物学院
2000年9月-2004年7月 农学学士，中国农业大学动物科技学院
返回顶部学术兼职
中国畜牧兽医学会动物繁殖学分会理事
国际生殖生物学协会（SSR）会员
浙江大学学报《农业与生命科学版》编委
返回顶部所获荣誉与主要奖励
Lalor Foundation Merit Award
Trainee Research Award Finalist
Larry Ewing Memorial Trainee Travel Fund (LEMTTF)
USDA NIFA NRI Merit Award
国家优秀自费留学生奖学金
参与完成的成果“体细胞克隆猪和转基因体细胞克隆猪技术平台的建立与应用”，获得神农中华农业科技奖一等奖（第十五完成人）
佛罗里达大学校友奖学金
参与完成的成果“体细胞克隆猪和转基因体细胞克隆猪技术平台的建立与应用”，获得神农中华农业科技奖一等奖（第十五完成人）
佛罗里达大学校友奖学金
返回顶部研究领域
主要从事动物繁殖学、细胞和胚胎工程相关的应用基础研究, 尤其关注奶牛、猪、小鼠等哺乳动物的早期胚胎发育调控机制的研究, 并注重推进动物克隆、干细胞和基因组编辑等前沿生物技术在动物育种方面的应用。
返回顶部完成及现有课题
浙江大学“百人计划”启动经费，主持
国家自然科学基金面上项目，2017-2020，主持
浙江大学高峰学科建设计划
中央高校基本科研业务费，2017-2018，主持
返回顶部学术论文
- Ding B#, Cao ZB#, Hong RY, Li H, XY Zuo, Luo L, Li YS, Huang WP, Li WY, Zhang K (corresponding author) and Zhang YH (corresponding author). WDR5 in porcine preimplantation embryos: expression, regulation of epigenetic modifications and requirement for early development. Biology of Reproduction. 2017 In Press (# equal contribution)
- Hand JM, Zhang K, Wang L, Koganti PP, Mastrantoni K, Rajput SK, Ashry M, Smith GW, Yao JB. Discovery of a novel oocyte-specific Krüppel-associated box domain-containing zinc finger protein required for early embryogenesis in cattle. Mechanisms of Development. 2017 In Press
- Cui W, Dai XP, Marcho C, Han ZB, Zhang K, Tremblay K, and Mager J . Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Scientific Reports. 6, 37396; doi: 10.1038/srep37396 (2016).
- Zhang K (corresponding author), Rajput SK, Wang SH, Folger JK, Knott JG, and Smith GW. CHD1 Regulates Deposition of Histone Variant H3.3 During Bovine Early Embryonic Development. Biology of Reproduction. In press, 2016
- Wang SH, Zhang K (corresponding author), Dai YP (corresponding author). Advances in genetic engineering of domestic animals. Frontiers of Agricultural Science and Engineering. In press; Review, Cover Picture, 2016
- Cui W, Pizzollo J, Han Z, Marcho C, Zhang K, Mager J. Nop2 is required for mammalian preimplantation development, Molecular Reproduction and Devevlopment. In press, 2016
- Zhang K, Rajput SK, Lee KB, Wang DL, Huang JC, Folger JK, Knott JG, Zhang JZ, and Smith GW. Evidence Supporting a Role for SMAD2/3 in Bovine Early Embryonic Development: Potential Implications for Embryotropic Actions of Follistatin. Biology of Reproduction. 2015 Oct;93(4):86
- Zhang K (corresponding author) and Smith GW. Maternal control of early embryogenesis in mammals. Reproduction, Fertility and Development. 2015 27(6) 880-896
- Ashry M, Lee KB, Mondal M, Datta TK, Folger JK, Rajput SK, Zhang K, Hemeida NAand Smith GW. Expression of TGFβ superfamily components and other markers of oocyte quality in oocytes selected by brilliant cresyl blue staining: Relevance to early embryonic development. Molecular Reproduction and Devevlopment 2015 Mar;82(3):251-64.
- Washkowitz AJ, Schall C, Zhang K, Wurst W, Floss T, Mager J, and Papaioannou VE. Mga is essential for the survival of pluripotent cells during peri-implantation development. Development 2015 142:31-40
- Yang QE, Ozawa Manabu, Zhang K, Johnson SE, Ealy AD. The requirement for protein kinase C delta (PRKCD) during preimplantation bovine embryo development.Reproduction, Fertility and Development, 2014 Aug 13. doi: 10.1071/RD14160. [Epub ahead of print]
- Lee KB#, Zhang K#, Folger JK, Knott JG, Smith GW. Evidence supporting a functional requirement of SMAD4 for bovine preimplantation embryonic development: A potential link to embryotropic actions of follistatin. Biology of Reproduction. 2014, 91(3):62 (# equal contribution)
- Lee KB, Wee G, Zhang K, Folger JK, Knott JG, Smith GW. Functional role of the bovine oocyte-specific protein JY-1 in meiotic maturation, cumulus expansion and subsequent embryonic development. Biology of Reproduction 2014 Mar 27;90(3):69
- Zhang K, Dai X, Trask MC and Mager J. Depletion of Suds3 reveals an essential role in early lineage specification. Developmental Biology, 373(2):359-72 (2013) Cover picture
- Zhang K, Harversat JM, Mager J. CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. Developmental Biology, 383(1):15-27 (2013).
- Zhang K, Ealy AD. Disruption of FGF signaling in COCs impacts oocyte maturation and developmental competence in vitro. Domestic Animal Endocrinology, 42(4):230-8 (2012)
- Zhang K, Ealy AD. Supplementing fibroblast growth factor 2 during bovine in vitro maturation promotes subsequent embryonic development. Open Journal of Animal Sciences, 2(2): 119-26 (2012)
- Zhang K, Hansen PJ, Ealy AD. Fibroblast growth factor 10 enhances bovine oocyte maturation and developmental competence in vitro. Reproduction 140: 815-826 (2010)
- Yang QE, Fields SD, Zhang K, Ozawa M, Johnson SE and Ealy AD. FGF2 promotes primitive endoderm development in bovine blastocysts. Biology of Reproduction 85(5):946-53 (2011)
- Zhang K, Ma YF, Wang SH, Lou YK, Wei HX, Sun XZ, Sun GJ, Zhao YH, Li Y, Dai YP, Zhang L, Li N. Effects of Leptin supplementation in in vitro maturation medium on meiotic maturation of oocytes and preimplantation development of parthenogenetic and cloned embryos in pigs. Animal Reproduction Science 101(1-2):85-96 (2007)
- Zhang K, Wei HX, Zhang YH, Wang SH, Li Y, Dai YP and Li N. Effects of Ghrelin on in vitro development of porcine in vitro fertilized and parthenogenetic embryos. Journal of Reproduction and Development 53(3):647-53 (2007)
- Zhang K, Zhang YH, Pan DK, Ma YF, Wei HX, Zhang J, Li XY, Wang SH, Li Y, Dai YP and Li N. Seasonal influence on the development of parthenotes and cloned embryos in pigs. Progress in Natural Sciences 17(10): 1172-1176 (2007)
- Wang SH, Zhang K, Ding FR, Zhao R, Li S, Li R, Xu LL, Song C, Dai YP, and Li N. A novel promoterless gene targeting vector to efficiently disrupt prnp gene in cattle. Journal of Biotechnology 163(4):377-85 (2013)
- Wang SH, Lv XQ, Zhang K, Lin TH, Liu XF, Yuan J, Dai YP, Li N. Knockdown of the prion gene expression by RNA interference in bovine fibroblast cells. Molecular Biology Report37:3193–3198 (2010)
- Ma YF, Li Y, Wei HX, Li QY, Fang R, Zhao R, Zhang K, Xue K, Lou YK, Dai YP, Lian LS and Li N. Effects of chemical activation and season on birth efficiency of cloned pigs. Science in China C: Life Sciences 52(7):657-64 (2009)
- Wang SH; Sun XZ; Ding FR; Zhang K; Zhao R; Li S; Tang B; Li R; Zhang L; Liu Y; Li J; Gao FL; Wang HP; Wang LL; Dai YP, Li N. Removal of selectable marker gene from fibroblast cells in transgenic cloned cattle by transient expression of CRE recombinase and subsequent effects on recloned embryo development. Theriogenology 72(4): 535-541 (2009)
- Wei HX, Zhang K, Ma YF, Li Y, Li QY, Dai YP and Li N. Stage-dependent effect of Leptin on development of porcine embryos derived from parthenogenetic activation and transgenic somatic cell nuclear transfer. Journal of Reproduction and Development 55(2):99-104 (2009)
返回顶部著作
1 张坤，李世杰. 第九章动物克隆原理与进展. (高级动物基因工程，科学出版社，李宁主编)
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