NAME: Zhenli Tu
QUALIFICATION: Dr. of Engineering
SPECIALITY: Molecular Biology;
Radiation Biology;
Functional Physiology & Resource of Insect.
OCCUPATION: Associate professor, MS. Advisor.
MAILING ADDRESS: College of Animal Sciences,
Zhejiang University,
Kaixuan Rd. 268, Huajiachi Campus,
Hangzhou 310029, P.R.China.
TEL: 86-13003655878 (Mobile)
FAX: +86-571-86971670
E-MAIL: tuzl@zju.edu.cn; tu514@yahoo.com.cn.
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Education and Academic Experience
2003.4-Present Associate professor, College of Animal Sciences, Zhejiang University,
(2004.9-2005.3: Foreign Specialist researcher, National Institute of Infectious Diseases, Japan;
2005.11-2006.4: Foreign Specialist researcher, National Institute of Infectious Diseases, Japan)
2000.4-2003.3 Post-Doctoral Fellow, Japan Atomic Energy Research Institute.
1997.4-2000.3 Ph.D, Shinshu University, Japan.
1996.2-1997.3 Visiting Scholar, Shinshu University, Japan.
1992.9-1996.1 Assistant professor, Zhejiang Agricultural University.
1989.9-1992.7 M.S, Zhejiang Agricultural University.
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CURRENT RESEARCH PROJECTS
1. 2006.1-2007.12, Cloing and High Level Expression of DNA Damage and Repair Gene of the Radiation-Resistant Bacterium Deinococcus radiodurans, Funded by Zhejiang province natural science foundation (Y305224).
2. 2004.4-2009.3, Study of DNA Damage Testing Model and Its Repair Mechanisms, supported by Ministry of Education, Culture, Sports Science and Technology, Japan.
3. 2004.1-2006.12, The Research of the Key tTechnology to Produce DNJ Medicine Effectively with the new Silkworm Biological Reactor, supported by Zhejiang Provincial Key Science and Technology Program (2004C22025).
4. 2004.1-2005.12, Study of Radiation Resistance Mechanisms of the Deinococcus radiodurans, supported by the Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry of China (J20040269).
5. 2004.7-2006.12, Cloing and Expression of DNA Damage and Repair new Gene of the Deinococcus radiodurans, Supported by Scientific Research Fund of Zhejiang Provincial Education Department (G20040392).
6. 2003.5-2005.12, Study of Radiation Bio-effect and DNA Damage Repair Mechanism of Deinococcus radiodurans, supported by Zhejiang University Science Foundation (ZJU-584601).
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RECENT PUBLICATIONS
1. ZY. Ye and ZL. Tu (2005): Study on the Secretion and the Rhizospheric Microorganisms of Mulberry Roots, ACTA Seri. Sinica, 31(1): 18-21.
2. DG. Liang, ZL. Tu, SL. Lu (2005): Change of Glutathione S-transferases(GST) and Glutathione(GSH) Synthetase Activities in the Hemolymph of the Flouride Poisoned Silkworm Larvae??CHN Seri.??26(2): 27-29.
3. ZL. Tu, MX. Shi, Y. Kobayashi and K. Kiguchi (2004): Antibacterial activity of silkworm hemolymph after hemopoietic organ being injured with radiosurgery, J. Appl. Entom., 128: 687-690.
4. ZL. Tu, YF. Huang, Y. Kobayashi (2004): Sensitivity of the Hemopoietic Organ of the Silkworm (Bombyx mori) to Heavy Ion Beams, J. Agri. Biotech., 12(5): 564-567.
5. ZL. Tu, ZY. Ye, MX. Shi, SL. Lu and Y. Kobayashi (2004): Hemocyte Function and Antibacterial Activity of Hemolymph After Destroying Hemopoietic Organ of Silkworm, Bombyx mori, With Heavy Ion Beam Radio-surgery, ACTA Seri. Sinica, 30(3): 266-269.
6. ZL. Tu, Y. Kobayashi, K. Kiguchi (2004): Application of heavy ion beams radio- surgery to function analysis of insect specific organ, Acta Ent. Sinica, 47(6): 844-848.
7. DG. Liang, ZL. Tu, SL. Lu and RQ. Xu (2004): Effect of ??-Glutamyl Transpeptidase Activity in the Hemolymph of the Fluorine Poisoning Silkworm larvae, Bull. Seri., 35(2): 20-22.
8. ZL. Tu, Y. Kobayashi, K. Kiguchi and H. Watanabe (2003): Effect of different heavy ions and track section on silkworm bombyx mori. Nucl. Instr. and Meth. in Phys. Res., B. 206: 591-595.
9. K. Kiguchi, K. Shirai, R. Kanekatsu, Y. Kobayashi, ZL. Tu, T. Funayama and H. Watanabe (2003): Radiosurgery by Heavy Ion Microbeams for Biological Study: Fate Mapping of the cellular Blastoderm Stage Egg of the Silkworm, Bombyx mori. Nucl. Instr. and Meth. in Phys. Res., B. 210: 312-315.
10. EJ. Ling, K. Shirai, R. Kanekatsu, Y. Kobayashi, ZL. Tu, T. Funayama, H. Watanabe and K. Kiguchi (2003): Why dose hemocyte density rise during the wandering stage of the silkworm, Bombyx mori? J. Insect Biotechnol. Sericol., 72:101-109.
11. EJ. Ling, K. Fukamoto, SQ. Xu, K. Shirai, R. Kanekatsu, Y. Kobayashi, ZL. Tu, T. Funayama, H. Watanabe and K. Kiguchi (2003): Regeneration of Hemopoietic Organs in the Silkworm, Bombyx mori, After the Locally Targeted Irradiation of Heavy Ion Beam, J. Insect Biotechnol. Sericol. 72:95-100.
12. Xu SQ, K.Kiguchi, Ling EJ, K. Shirai, K. Fukamoto, Tu ZL (2003): Repair and Regneration of Heavy Ion Beam locally Irradiated Embryonic Hemopoietic Organs of Silkworm, Bombyx mori, J. Radiat. Res. Radiat. Process, 21(2): 143-147.
13. ZL. Tu, Y. Kobayashi, K. Kiguchi, and H. Watanabe (2002): Applicability of radiosurgery with heavy ion beams to inactivate specific organs in living organisms. Radait. Environ. Biophys., 41: 231-234.
14. ZL. Tu, Y. Kobayashi, K. Kiguchi, H. Watanabe and K. Yamamoto (2002): Effects of heavy-ion radiosurgery on the hemopoietic function of the silkworm Bombyx mori. J. Radiat. Res., 43: 269-275.
15. Xu SQ, K.Kiguchi, Ling EJ, K. Shirai, K. Fukamoto, Tu ZL (2002): Physiological Effect of Heavy Ion Beam Irradiation on Larval Hemopoietic Organs of Silkworm, Bombyx mori, ACTA Seri. Sinica, 28 (3): 194-198.
16. Xu SQ, K.Kiguchi, Ling EJ, K. Shirai, K. Fukamoto, Tu ZL (2002): Effect of Local Heavy Ion Beam Irradiation on Hemopoietic Function of the Larval Hemopoietic Organs of Silkworm, Bombyx mori, ACTA Seri. Sinica, 28 (4): 298-300.
17. ZL. Tu, Y. Kobayashi, H. Watanabe, K. Kiguchi, and K. Yamamoto (2001): Radiosurgery applications of the local irradiation by heavy ion beams: Decrease of antibacterial activity of hemolymph after local irradiation on the hemopoietic organs of larvae of silkworm, Bomyx mori. J. Radiat. Res., 42(4): 523.
18. Y. Kobayashi, M. Taguchi, H. Watanabe, K. Yamamoto, S. Yamasaki, ZL. Tu, Y. Kinjoh and K. Kiguchi (2000): Cell surgery applications of heavy ion microbeams. Radiat. Res., 182-186.
19. K. Kiguchi, Y. Kinjoh, K. Masahashi, ZL Tu, H. Tamura, K. Shirai, R. Kanekatsu, Y. Kobayashi, M. Taguchi and H. Watanabe (2000): Fate mapping of the cellular blastderm stage egg of the silkworm, Bombyx mori: by localized irradiation of heavy ion microbeam. JAERI-Review 2000-024: TIARA Annual Report, 1999, 51-53.
20. ZL. Tu, S. Yamasaki, K. Shirai, R. Kanekatsu, K. Kiguchi, Y. Kobayashi, M. Taguchi and H. Watanabe (1999): Affects of general and local irradiation of heavy ion beams on the development and morphogenesis of the silkworm, Bombyx mori. J. Seri. Sci. Jpn., 68: 443-453.
21. ZL. Tu, K. Shirai, R. Kanekatsu, K. Kiguchi, Y. Kobayashi, M. Taguchi and H. Watanabe (1999): Effects of local heavy ion beam irradiation on the hemopoietic organs of the silkworm, Bombyx mori. J. Seri. Sci. Jpn., 68: 491-500.
22. K. Kiguchi, T. Shima, Y. Kinjoh, ZL. Tu, S. Yamasaki, Y. Kobayashi, M. Taguchi and H. Watanabe (1999): Effects of heavy ion microbeams on embryogenesis in the silkworm, Bombyx mori: Morphological changes of the nuclei and cells after spot irradiation. JAERI-Review, 99-025, 53-55.
23. Y. Kobayashi, M. Taguchi, H. Watanabe, K. Yamamoto, S. Yamasaki, ZL. Tu, Y. Kinjoh, K. Kiguchi, M. Kawai, H. Uchimiya (1998): Application of a collimated heavy ion microbeam systemt at TIARA for local irradiation of biological targets. J. Radiat. Res., 39(4): 320.
24. K. Kiguchi, S. Yamasaki, ZL. Tu, Y. Kinjoh, Y. Kobayashi and H.Watanabe (1998): Effects of heavy ions on embryogenesis in the silkworm, Bombyx mori : Comparison of radiation effects among three different ions. JAERI-Review, 98-016, p38-40.
International Congress
1. M. Oikawa, H. Fujimoto, ZL. Tu, K. Saito, R. Watanabe, K. Tsuchida, M. Nakagaki, N. Takada, E. Yamauchi, H. Maekawa: Detection of DNA strand breaks using real-time PCR amplification for irradiated plasmid pBR322 and application for its structural analysis. 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, (20th IUBMB & 11th FAOBMB, Kyoto Japan, June 18-23, 2006), p312.
2. M. Oikawa, H. Fujimoto, ZL. Tu, K. Saito, R. Watanabe, E. Yamauchi, K. Tsuchida, M. Nakagaki, N. Takada, T. Shimada and H. Maekawa: Detection of DNA strand breaks using real-time PCR amplification for irradiated plasmid pBR322 and application for the genomic DNA analysis. Joint meeting in Radiation Biology for the Netherlands Radiobiological Society, (Netherlands, April 25-28, 2006). p58.
3. M. Oikawa, ZL. Tu, H. Fujimoto, K. Sitou, E. Yamauchi, R. Watanabe, K. Tsuchida, M. Nakagaki, N. Takada and H. Maekawa: Detection of DNA strand breaks using real-time PCR amplification for irradiated plasmid pBR322 and its structural analysis. Proceedings of The 1st Asian congress of radiation Research(Hiroshima Japan, ACRR-2005, Nov. 16-17, 2005 ), p119.
4. ZL. Tu., Kobayashi, Y., Kiguchi, K. and Watanabe, H: Effect of different heavy ions and track section on silkworm bombyx mori., The 13th International Conference on Ion Beam Modification of Materials (IBMM-2002, kobe, Japan, Sep. 1-6, 2002). p103-104.
5. Y. Narumi, ZL. Tu and K. Satoh: Isolation of a small cryptic plasmid from Deinococcus radiopugnans and development of shuttle vectors between Escherichia coli-Deinococcus grandis for stable expression of foreign genes in D. grandis. The 4th International Congress on extremophiles (Extremophiles, Naples, Sep. 22-26, 2002), p234.
6. K. Kiguchi, K. Shirai, R. Kanekatsu, Y. Kobayashi, ZL. Tu, T. Funayama and H. Watanabe: Radiosurgery by Heavy Ion Microbeams for Biological Study: Fate Mapping of the cellular Blastoderm Stage Egg of the Silkworm, Bombyx mori. 8th International Conference on Nuclear microprobe Technology & Applications, (ICNMTA-2002, Takasaki Japan, Sep. 8-13, 2002), p162.
7. Y. Kobayashi, T. Funayama, ZL. Tu, M. Taguchi, H. Watanabe, K. Yamamoto, Y. Kinjoh, K. Masahashi, H. Tamura, and K. Kiguchi: Radiosurgery applications of heavy ion microbeams: Fate mapping of the silkworm egg with local irradiation of heavy ions, 13th Symposium on Microdosimetry (An Interdisciplinary Meeting on Radiation Quality, Molecular Mechanisms, Cellular Effects and Health Consequence of Low Level Ionising Radiation), (MICROS-2001, Stresa (Lago maggiore), Italy, May 27-June 1, 2001), L2.
8. ZL. Tu, K. Shirai, R. Kanekatsu, K. Kiguchi, Y. Kobayashi, M. Taguchi, H. Watanabe: Radiosurgery by heavy ion beams for biological study of the silkworm, Bombyx mori. Proceedings of The 4th China International Silk Conference (Silk Road to the 21st Century), (CISC-4, Yinchuan, China, May 14-19, 2000), p13-17.
9. Y. Kobayashi, M. Taguchi, H. Watanabe, K. Yamamoto, S. Yamasaki, ZL. Tu, Y. Kinjoh and K. Kiguchi: Cell surgery applications of heavy ion microbeams. 11th International Congress of Radiation Research (ICRR), Congress Proceedings of the 11th International Congress of Radiation Research (ICRR-11, Dublin, Ireland, July 18-23, 1999) 2, p182-186.
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LECTURES
Course for Undergraduate
1. Biology of Microbial Resources
2. Resource Entomology
Course for Master and doctoral students
1. Comparative Molecular Biology
2. Biochemistry Engineering and Utilization of Bio-resources
3. Advance on Resource &Utilization of Entomology