Xiaofeng WU, B.Sc., M.Sc. Ph.D.

PERSONAL DATA

Sex: Male

Date of birth: 02 March 1966

Nationality: Chinese

CURRENT POSITION AND POSTAL ADDRESS

Professor of Insect Molecular Biology and Biotechnology

Deputy Director, Department of Specific Economic Animal (including Silkwom and Bee)  

Zhejiang University, Huajiachi Campus

Kaixuan Road 268, Hangzhou

310029 Zhejiang

P. R. China

Telephone: +86 571 86971658

Telefax: +86 571 8697 1647

E-mail: wuxiaofeng@zju.edu.cn

EDUCATION

Ph.D. (Applied Biology), Kyoto Institute of Technology, Japan (Mar. 2001)

M.S. (Entomology), Zhejiang Agricultural University, China (Jul. 1990)

B.S. (Sericulture), Zhejiang Agricultural University, China (Jul. 1987)

QUALIFICATIONS AND CAREER

Professor, Zhejiang University, China (Dec. 2006 ¨C present)

Associate Professor, Zhejiang University, China (Jun. 2001 ¨C Nov. 2006)

Postd. Researcher, University of California,Riverside, USA (May. 2002 ¨C May. 2003)

Visiting Researcher, Kyoto Institute of Technology, Japan (Jan. 1997 ¨C Feb. 1998)

Lecturer, Zhejiang Agric University, China (Nov. 1993 ¨C Dec. 1996)

MANAGERIAL RESPONSIBILITIES

Deputy Director, Department of Specific Economic Animal, Zhejiang University (Jun. 2006 ¨C present)

Assistant Director, Institute of Sericulture and Apiculture, Zhejiang University (Dec. 2005¨C present)

HONORS AND AWARDS

l           Grant of New-Century Training Programme Foundation for the Talents (2006)

Ministry of Education, China

l           Third-class Award of Promoting Science & Technology (2005)

Zhejiang Provincial Government

l             Excellent Teacher PrizeZhejiang University (2005)

l           Second-class Award of Promoting Science & Technology (2004)

Shandong Provincial Government

l

OVERSEAS VISIT AND EXPERIENCE

l         In 1992, invited by UNDP and ESCAP to attend the Expert Group Meeting on Post-cocoon Operations and Sixth Session of the Regional consultative Group on Silk held in Manila, Philippines in October. In this meeting, as a representative of China, I presented a country paper -?°Post-cocoon operation in China?±.

l         Invited by the Central Silk Board, Ministry of Textile, India to observe the local sericulture activities and put forward pratical suggestions for further development, I visited india in September, 1994.

l         Invited by BRAC(Bangladesh Rural Advancement Committee), I visited this country in November,1994. By observation of the local sericultural activities, we drafted a report and helped them to make a long-term developmental plan.

l         Participated in the International Entomology Committee, I participated in the 19th International Congress of Entomology held in Beijing, China, June 28-July 4,1992, and gave a presentation on ?°Sericulture production in China?±.

l         Participated in 1st International Symposium on Sericultural Science held in Hangzhou, China. Oct.6-10,1996, and gave a presentation on ?°Important protective enzymes in the silkworm, Bombyx mori L.?±

l         Visiting Researcher, Kyoto Institute of Technology, Japan (Jan. 1997 ¨C Feb. 1998)

l         Postd. Researcher, University of California, Riverside, USA (May. 2002 ¨C May. 2003)

RESEARCH ACTIVITIES

1. 2002.01-2006.12  Construction of a host range-expanded hybrid baculovirus of BmNPV, and knockout of cysteinase gene for more efficient expression, supported by Ministry of Agriculture of China (2003-Z50) and Zhejiang Provincial Key International Cooperation Program(No. 2002C24003).

2. 2002.01??2004.12  Targeting of human FGF gene into silkworm, bombyx mori L  by using a transfer vector, supported by the Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry of China

3. 2003.01-2006.12.  Transgenic silkworm, supported by Zhejiang Provincial Natural foundation (301306).

4.   2002.01??2005.12  Research on some key techniques for utilizing the silkworm as ?°biofactory ?± to produce useful protein by using recombinant baculovirus??supported the Scientific Research Foundation for Returned Overseas Chinese Scholars, Zhejiang Province.

5.       2004.01-2006.12  Molecular mechanism of antiviral activity in linsect (silkworm as model).

6.       2005.08-2008.07  Proteomics analysis of midgut of fifth-instar silkworm Bombyx mori larva, supported by National Basic Research Program (2005CB121003).

7.       2005.08-2006.12 Development of a rapid and efficient BmNPV Bac-to-Bac baculovirus expression system for application in mulberry silkworm, Bombyx mori. Supported by Ministry of Agriculture of China (2005-C5).

8.       2006.01-2008.12 Key techniques for production of recombinant human VEGF in silkworm, supported by Provincial Key International Cooperation Program of Zhejiang (2006C24015).

9. 2006.01-2006.12 Molecular cloning and analysis of an antiviral protein in wild silkworm Bombyx mandarina Moore, supported by Natural Scientific Foundation of China (30671191) and Zhejiang Provincial Natural foundation (Y305050).

List of recent publications

1. Ryo Takano, Tomomi Nagai, Xiaofeng Wu, Xinyan Xu,Nguyen Tien Huy, Kaeko Kamei and Saburo Hara. Sulfation of polysaccharides using monomethyl sulfate. Journal of Carbohydrate Chemistry. 2000, 19(9),1185-1190 (SCI, IF 1.017) (3/7)

2. Xiaofeng Wu , Kaeko Kamei, Hideki Sato, Shin-ichi Sato, Ryo Takano, Masatoshi Ichida, Hajime Mori, and Saburo Hara. High-level expression of human acidic and basic fibroblast growth factors in the silkworm, Bombyx mori L. using recombinant baculovirus. Protein Expression and Purification (USA). 2001, 21(1): 192-200. (SCI, IF 1.553/2005) (1/8)

3. Kaeko Kamei, Xiaofeng Wu, Xinyan Xu, Kazuhiro Minami, Nguyen Tien Huy, Ryo Takano, Hisao Kato, and Saburo Hara The analysis of heparin-protein interactions using evanescent wave biosensor with regioselectively desulfated heparins as ligands. Analytical Biochemistry (Academic Press)2001 295, 203-213  (SCI, IF 2.67/2005) (2/8)

4. Wu Xiaofeng, Zhaozheng Yin, Cuiping Cao, Ling Huang, Xingmeng Lu, Jianxin Liu_, Weizheng Cui. Expression of human VEGF165 in silkworm (Bombyx mori L.) by using a recombinant baculovirus and its bioactivity assay. 2004, Journal of Biotechnology, 111(3):253-61. (SCI, IF 2.687/2005)  

5. Xiaofeng Wu, Cao Cuiping , V. Shyam Kumar and Cui Weizheng, 2004. An innovative technique for inoculating recombinant baculovirus into the silkworm Bombyx mori using lipofectin, Research in Microbiology. 155(6):462-6.?¨SCI, IF 2.426/2005??  

6. Wu Xiaofeng, Cao Cuiping, Xu Yaxiang, Lu Xingmen, 2004. Construction of a host  

range-expanded hybrid baculovirus of BmNPV and AcNPV, and knockout of Cysteinase gene f or more efficient expression. Sci China C Life Sci. 47(5): 406-415. ?¨SCI, IF 0.482/2005??

7. Yizhen Wang, Xiaofeng Wu, Guangfu Liu, Cuiping Cao, Haiqing Huang, Zirong Xu, Jianxin Liu. Expression of porcine lactoferrin by using recombinant baculovirus in silkworm, Bombyx mori L., and its purification and characterization. Appl Microbiol Biotechnol. 2005, 65: 385-389 (SCI, IF 2.586/2005)   

8. Huahua Du, Xiaofeng Wu^*, Weifen Li, Wei Dai. 2006. Increased resistance to white spot syndrome virus in Procambarus clarkii by injection of envelope protein VP28 expressed using recombinant baculovirus. Aquaculture. 260, 39-43.?¨SCI??IF 1.374/2005??

9. Cuiping Cao, Xingmeng Lu, Na Zhao, Huipeng Yao, Xiaofeng Wu,*and Yeping Tan. Development of a rapid and efficient BmNPV baculovirus expression system

for application in mulberry silkworm, Bombyx mori. 2006, Current Science. 91(12):1692-1697 (SCI,IF 0.687/2005) 

10. Bing Wang, Xiaofeng Wu*, Na Zhao. Enhanced effect of fluorescent whitening agent on peroral infection for recombinant baculovirus in the host Bombyx mori. 2007, Current Microbiology. Vol. 54, pp. 5-8 (SCI,IF 1.059/2005)

11. Wu Xiaofeng, Cao cui-ping. Targeting of human aFGF gene into silkworm, Bombyx mori L.  through homologous recombination. Journal of Zhejiang University SCIENCE. 2004, 5(6):644-650.  

12??Yao Huipeng, Xiaofeng Wu, GOKULAMMA K. Antiviral activity in the mulberry silkworm, Bombyx mori L. J Zhejiang Univ SCIENCE A 350 2006 7(Suppl. II): 350-356

13. Xiaofeng Wu , Xu Yaxiang, Shen Guoxin, Kaeko Kamei, Ryo Takano and Saburo Hara. Surface plasmon resonance analysis to evaluate the importance of heparin sulfate groups' binding with human aFGF and bFGF . 2003  J Zhejiang Univ Sci. 4: 86-94.

LECTURES

Course for Undergraduate

1.   Bioresources and Gene Engineering

2.   Animal Bioreactor Engineering

Course for Master and doctoral students

1. Animal Molecular Cell Biology

3. Advance on Animal Biotechnology

3. Animal Molecular Biology

4. Applied Animal Biotechnology

5. Bioreactor and Gene engineering