Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig
Jianzhao Liu,1,* Yuanxiang Zhu,2,* Guan-Zheng Luo,1,* Xinxia Wang（王新霞）,1,3,* Yanan Yue,1 Xiaona Wang,2 Xin Zong,3 Kai Chen,1 Hang Yin,1Ye Fu,1 Dali Han,1 Yizhen Wang（汪以真）,a,3 Dahua Chen,b,2 and Chuan Hec,1
1Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
2State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
3Key Laboratory of Animal Nutrition and Feed Sciences, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, China
*These authors contributed equally to this work
期刊：NATURE COMMUNICATIONS
Impact Factor (影响因子): 12.12（2016年）
出版年：OCT 2016
摘要：DNA N6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ～0.1?0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression of the embryo development. During this process a large fraction of 6mAs locate in repetitive regions of the genome.